WebApr 4, 2024 · The latter can be summarized as three major ferroptosis-relevant ‘antioxidant axes’ [ 14 ], i.e., the cyst (e)ine/GSH/GPX4 axis, the GCH1 (GTP cyclohydrolase I)/BH 4 (Tetrahydrobiopterin)/DHFR (Dyhydrofolate reductase) axis and the FSP1 (ferroptosis suppressor protein)/CoQ 10 (Coenzyme Q10) axis (for details including potential … WebAbstract Hypoxia is pivotal to the pathogeneses of myriad disorders, especially hypoxic cerebropathy. Much is known about the damage to the blood–brain barrier (BBB) in response to hypoxia. Studies...
mTORC1 couples cyst(e)ine availability with GPX4 protein …
WebAug 3, 2024 · GSH: The main cofactor of system X c− /GSH/GPX4 axis GSH is a core antioxidant that is formed by condensation of Glu, Cys, and Gly. GSH, as the main cofactor of GPX4, plays the role of an electron donor or receptor by conversion between G-SH and GS-SG, making it important to fight oxidative stress ( Deponte, 2013 ). WebMar 11, 2024 · In this study, we revealed that cyst(e)ine promotes the synthesis of not only GSH but also GPX4 protein. Mechanistically, we showed that cyst(e)ine promotes GPX4 … jive into the night ultimix
The Role of Ferroptosis in Blood–Brain Barrier Injury
WebApr 27, 2024 · Our recent study linked cyst (e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1... WebApr 10, 2024 · GPX4 is a selenocysteine-containing protein with strong antioxidant activity. GPX4 was first discovered in 1983 by Fulvio Ursini and colleagues, initially named phospholipid glutathione peroxidase (PHGpx) [ 14 ]. Further, GPX4 was dictated in 2012 and 2014 as a core regulator of ferroptosis by Stockwell and colleagues [ 8, 15 ]. WebMar 11, 2024 · Mechanistically, we find that cyst(e)ine activates mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and promotes GPX4 protein synthesis at least … instant pot steam potstickers