WebMechanistically, we find that cyst(e)ine activates mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and promotes GPX4 protein synthesis at least partly through the Rag-mTORC1-4EBP ... WebCystine is the oxidized derivative of the amino acid cysteine and has the formula (SCH 2 CH(NH 2)CO 2 H) 2.It is a white solid that is poorly soluble in water. As a residue in …
mTORC1 couples cyst(e)ine availability with GPX4 protein
WebUltimately, we assess the feasibility of combining nanomaterials with ionizing radiation to induce ferroptosis, paving the way for future research. WebMar 11, 2024 · Fig. 3: Cyst (e)ine promotes GPX4 protein synthesis partly through Rag-mTORC1-4EBP signaling. a UMRC6 cells were cultured in media with indicated … cannabis infused tincture
The Metabolic Underpinnings of Ferroptosis - ScienceDirect
WebDescription Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 protein synthesis is highly inefficient and energetically costly. How cells coordinate GPX4 synthesis with nutrient availability remains unclear. WebFeb 28, 2024 · GPX4 is a GSH-dependent peroxidase whose activity and expression are regulated by GSH. The main function of GPX4 is to reduce phospholipid hydroperoxide production, ... The cyst(e)ine/GSH/GPX4 system was considered the critical regulatory molecule in the process of ferroptosis. WebJan 1, 2024 · The cyst ( e )ine/GSH/GPX4 antioxidant axis is one of the most important axes for ferroptosis defense, which is fueled by NADPH. Although lipid peroxidation has been reported as one major effector by which UV contributes to photoaging and skin cancer, it remains unclear if ferroptosis is involved in UV irradiation-induced skin damage. cannabis infused vegetable oil recipe